Neuropathic Pain

Almost 50 million Americans experience chronic or severe pain, according to the National Institutes of Health’s (NIH) National Center for Complementary and Integrative Health. The report, published by the American Pain Society, estimated that 25 million suffered daily chronic pain while over 23 million felt severe pain every day. NIH also states that experiencing pain regularly can have a negative impact on sleep, cardiovascular health, brain function, sexual function and general quality of life.

What Is Neuropathic Pain?

Pain is a warning signal sent to the brain that indicates something in the body isn’t right. Nociceptors Areare the nerve pain receptors that set off these signals when provoked by trauma, burns, inflammation, or infection. Acute pain can be caused by such actions as a hammer hitting a thumb. After the initial cause of pain ceases, the pain itself usually diminishes. Chronic pain lasts much longer. Pain signals continue to be generated and sent toward the brain at a more powerful level, even after the original source of the pain has long healed. Pain gets worse. Thus, the most common cause of chronic pain is inadequately treated acute pain. It can also be caused by factors including injury or illness, such as a back sprain, arthritis or disease like cancer.

When the nociceptors that send pain signals to the brain activate themselves, the result is neuropathic pain. Sensations of itching, tingling, stabbing, aching, or devastating pain may result, not from a particular cause but from unprovoked activity by the nociceptors. This has a definite psychological impact and may result in depression and other unpleasant conditions.

Diagnosing Neuropathic Pain

Several methods can be used to diagnose neuropathic pain. Physicians should be told the frequency and severity of the pain, where it emanates and if it radiates to other areas of the body. The type of pain, such as burning, shooting, tingling or crushing is taken into consideration, as well as anything the patient does that seems to improve it. Medical conditions, including previous strokes, shingles and diabetes are also considered.

A physical exam incorporating neurological tests, an evaluation of muscles spasms and blood tests are also used to diagnose neuropathic pain. Imaging methods, such as X-rays, ultrasound, CT, and MRI are used to focus on a limb with chronic neuropathic pain, but are also used to identify any structural conditions (nerve compression) or masses (benign and malignant tumors) that may be causing chronic pain.

Additionally nerve conduction studies can determine if pain signals are being sent to the brain properly. Electromyography is another technique that tracks electrical activity of muscle fibers. This may determine whether the pain is related to nerves or muscles.

Treatment Options

Neuropathic pain can be managed and treated several different ways. Behavioral and physical therapy programs may be prescribed, as well as medication. Neuromodulation is another option. With this method, transcutaneous electrical nerve stimulators (TENS units) can send impulses to the spine to block the painful impulses. Spinal neuro-stimulation using implantable electrodes can do the same but target the painful area more specifically.


Preventing neuropathic pain can begin by immediately and aggressively treating acute pain after it occurs. That prevents acute pain from becoming chronic. Further, relieving acute nerve compression or inflammation can help in warding off chronic and neuropathic pain.

Treating emotional and psychological conditions, such as hopelessness and depression, also can prevent neuropathic pain. Chronic pain syndrome can have a negative impact on marriage and relationships, employment and financial stability. There is a vicious cycle of pain and depression and then more pain, so improving these issues can also prevent neuropathic pain.

To learn more about neuropathic pain, log on to and visit Neuropathy Pain Institute under the Institutes and Divisions tab.

Pain Is a Warning

illustration of neuropathic painTo understand neuropathic pain, it is necessary to understand “normal” pain, that is, what pain is and how it functions in normal circumstances. Pain is a warning. Its unpleasantness gets one’s attention in order for one to learn what can injure or damage the physical body. It is of significant evolutionary importance.

All pain is perceived in the brain; before that, it is just a signal from a point of injury. At the brain, this signal is used to locate where the pain is, how severe the injury is, and how painfully it should be perceived. Nociceptors are the nerve pain receptors that set off these signals when provoked by trauma, burns, inflammation, or infection.

Pain’s Path

From the nociceptors, the signal travels up that area’s nerve to the spinal cord, and where it enters is met by some altering, competitive signals. One of these is the brain’s inhibitory stimulus. (Once warned by pain, the brain makes an individual functional by dampening this pain so that he or she can get away from a source of injury.) Another alteration at the site is a connecting nerve called an “interneuron,” which also diminishes the pain as the signal crosses to the other side of the spine to rise up through spinal nerve tracts to the brain, the whole circuit giving feedback between the pain stimulation and its inhibition.

As an example, hitting one’s thumb results in an immediate pain signal (from an evolutionary standpoint, to stop hitting one’s thumb). Immediately after, the pain is not quite as severe. This is not because the thumb is any less injured; it is because of the dampening processes in action.

When Acute Pain Becomes Chronic Pain

If repeated signals continue to bombard the spinal areas where the pain is dampened, this system can become overwhelmed and recruit other previously inactive pain receptors in the spine. As this happens, the inhibitory interneuron changes into an “amplification” interneuron and pain signals continue to be generated and sent toward the brain at a more powerful level, even after the original source of the pain has long healed. Pain gets worse. Thus, the most common cause of chronic pain is inadequately treated acute pain.

Neuropathic Pain

When pain is due to nerve nociceptors firing off their pain signals by themselves, this is what is called neuropathic pain. Neuropathic pain will present as what the nociceptors involved in pain generation were designed to do–initiate sensations of itching, tingling, stabbing, aching, or devastating pain, but instead of initiating these sensations due to some injury, they have begun initiating them without provocation.

The Psychological Toll of Neuropathic Pain

Acute pain causes anger (the example of hitting the thumb with a hammer). Chronic pain is associated with depression. Overactive areas of the brain, as with neuropathic pain, “recruit” other areas from emotional centers, which is why a third of those with chronic pain have depression. Depression makes the perception of pain worse, and worse pain makes the depression worse. It becomes a vicious cycle that can only be stopped when both pain and its psychological effects are treated together.

How Is Neuropathic Pain Diagnosed?

It is impossible to prove someone is in pain, because pain is a subjective perception. The pain doctor is obligated to believe his or her patient, however, and to devise strategies to manage it. It is more helpful, however, for the doctor to understand what is going on in a patient’s pain syndrome than to label it with a diagnosis.

The Patient History

A history and physical exam are the initial diagnostic tools. The doctor will learn when the pain began, where it’s located now, and its progression, nature, and severity. It can be used to note changes due to pain, such as in skin, hair, nails, skin color, sweating, temperature changes, and muscle spasm. The pain itself requires a specific list of questions whose answers are helpful in understanding the pain:

  • Frequency of pain: is it intermittent or continuous?
  • Where is the pain located and does it radiate to other areas?
  • What is the quality of the pain–burning, tingling, shooting, crushing, stabbing, etc.?
  • What makes it better? What makes it worse?
  • How has it changed life at home, in a marriage or relationship, in employment?
  • Are there any medical conditions that make neuropathic pain more likely, such as diabetes? Herpetic outbreaks–simplex or zoster (shingles)? Previous stroke or closed head injury?
  • How has it affected the patient besides its discomfort–depression, anger, or hopeless?

The Analog Pain Score

Pain is known as the 5th vital sign, after temperature, pulse rate, respiratory rate, and blood pressure. A patient will be asked to assign a number to pain severity, 0 being absent and 10 being the worst conceivable pain. This is helpful in determining the urgency of management and as an interval score in judging the success of any treatment.

The Physical Exam

The physical exam incorporates a neurological assessment that attempts to find a cause for the neuropathic pain. Since most neuropathic pain is of a mysterious origin, physical findings are often unhelpful. An evaluation of normal nerve function is limited to a check of reflexes and perception of pinpricks or other tactile testing devices. A previous stroke may only become known by the neurological findings sought when evaluating a patient for neurologic pain. Any damage to the brain can alter pain perception, the dampening process, or the psychological impact to pain’s perception.


Muscle spasm is a frequent condition associated with neuropathic pain, as patients will overtax muscles used to splint away from the painful area, overwhelming their capacity. This causes muscles to become acidotic which results in painful cramping. Occasionally the muscle spasm is so painful that the patient seeks help for it instead of the neuropathic pain that has caused it.

Trigger Points

Occasionally, the path of a painful nerve tract can demonstrate small lumps of inflammatory nerve along its path, called trigger points. These are especially sensitive but can be used to advantage by injecting them with anesthetic or just in breaking them up by the needle alone.

Blood Tests

Blood tests are indicated with neuropathic pain to identify any underlying conditions that make it more likely, such as diabetes (fasting glucose or hemoglobin A1c level) and rheumatic arthritis (RA factor–rheumatoid factor, C-reactive protein–CRP, erythrocyte sedimentation rate–ESR).

Drug testing is required when patients are on chronic pain medications. Drug diversion is a serious problem resulting in an overdose crisis, and pain doctors will screen their patients to assure the medication prescribed is being taken and that no unprescribed medications or illicit drugs (cocaine, methamphetamines) are being taken. This is not for strictly legal reasons, but for legitimate care of those in whom addiction and dependence may have influenced their behavior and put them in danger.


X-rays, ultrasound, CT, and MRI are used to focus on a limb with chronic neuropathic pain, but are also used to identify any structural conditions (nerve compression) or masses (benign and malignant tumors) that may be causing chronic pain.

Neurophysiologic Testing

  • Nerve conduction studies can determine if the signal is traveling through the nerve normally, whether it is delayed, or whether the signal is weak or amplified.
  • Electromyography is used to evaluate the electrical activity of muscle fibers innervated by nerves to determine whether the pain is primarily a nerve disease or a muscular disease. It is especially helpful in assessing muscle spasm.

How Can I Manage Neuropathic Pain?

Neuropathic pain is a complicated cross-traffic of nerve and muscle pathology, social dysfunction, mood alterations, and depression. When a patient fails to get relief, hopelessness amplifies the perception of pain. The treatment for neuropathic/chronic pain requires a multidisciplinary approach that includes medication, physical therapy, behavioral and psychological intervention, and surgical therapies that can include neurostimulators and implanted pumps for medication delivery into the spinal fluid.

Of all of these treatment modalities, the main three are medication, behavioral/psychological therapy, and physical therapy.


The line between chronic pain and neuropathic pain is often blurred, since neuropathic pain is a type of chronic pain. Opioid medication and other analgesics, a standard treatment for severe, unremitting pain, is often used in treating neuropathic pain, too. Anticonvulsants affect the nerve transmission of pain; anti-anxiety agents and antidepressants also have a role; and antispasmodics help when muscle spasm is involved. Since strong medication has an increasing potential for side effects, complications, and abuse, the usual protocol calls for a medication “pyramid” with multiple tiers of drugs to try, from the safest to the ones requiring the most scrutiny.

The types of drugs used in neuropathic pain include non opioid analgesics (acetaminophen, NSAID), anticonvulsants (gabapentin, pregabalin), antidepressants, antispasmodics, and even medicinal marijuana.

Neuropathic pain, when initially treated with antidepressants, use the ones which inhibit the reuptake (keep levels higher) of neurotransmitters known to affect pain–serotonin and norepinephrine. (These are neurotransmitters found in the inhibitory pathway from the brain.)

Behavioral Therapy

Biofeedback and cognitive-behavioral therapy and psychological therapy are useful for both the physical pain and the psychological impact that augments it.

Physical Therapy

The goal of pain management is not to make one pain-free, as this is seldom accomplishable. Instead, the goal is to make a patient functional, either in spite of the pain or by mitigating its severity. One of the best approaches to restoring functionality is via physical therapy, which not only uses active and passive motion to reduce pain, but trains the patient how to alter lifestyle to keep the improvements in place.


Transcutaneous electrical nerve stimulators (TENS units) can send impulses to the spine to block the painful impulses. Spinal neurostimulation using implantable electrodes can do the same but target the painful area more specifically. Deep brain stimulation and other novel approaches are being investigated.

Invasive Intervention

Besides implantable stimulators or pain pumps, interventional methods include injections of steroids and/or local anesthetic into the problem sites. Nerve ablation can effectively stop the pain transmission but can run the risk of affecting other nerve functions when the nerve has a mixed purpose of both sensory and motor roles.

Neuropathic Pain Prevention

Since the most common cause of chronic pain, including neuropathic pain, is primarily due to neglected, ignored, or inadequately treated acute pain, prevention is accomplished by treating acute pain before it can become chronic. Therefore, the prevention of neuropathic pain is by aggressively treating acute syndromes that result from trauma and injury, burns, chemical exposure, fractures, nerve compression, and other painful sources.

Acute nerve compression can be relieved surgically to prevent further pain. Medication can mitigate acute pain’s severity so that the spinal inhibitory pathways don’t become overwhelmed, setting up the dominoes that fall to result in chronic pain.

Any acute inflammation associated with injury, while serving as part of the healing process, can continue past its welcome and usefulness to result in neuropathic pain, so any inflammatory conditions that last beyond what is expected in an injury or infection should be cooled down with non-steroidal anti-inflammatories or corticosteroids.

Some complications of injury result in pain syndromes that are hard to explain or treat, such as complex regional pain syndrome (CRPS), which causes expanding areas of pain, motor dysfunction, and other manifestations. Early mobilization (physical therapy) after a limb injury may prevent CRPS. Nerve blocks may pause its progression, and behavioral therapy is useful to limit its impact or longevity.

Treatment of hopelessness is important in neuropathic pain, since a chronic pain syndrome can jeopardize relationships and threaten employment and income. The pain experience is consuming, but adding divorce and other estrangements and stopping the flow of income and support will severely impact anyone’s coping skills negatively, making the vicious cycle of pain-depression-pain spiral down more viciously. Because of the codependent nature of pain and the changes in the brain ic creates, treating neuropathic pain physically and the social and financial deterioration it causes, psychologically, at the same time, is the best way to prevent worsening of an already-challenging situation.

casino siteleri